H3K27 Demethylases, at Long Last

H3K27 Demethylases, at Long Last

Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation o...

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression profile of an individual cell or cell lineage. Thus, differences in these modifications have a pivotal role in determining and maintaining cell fate ...

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the innate and adaptive immune systems. Some studies have reported that NK cell activation and cytokine secretion are controlled epigenetically but...

The expression and significance of histone H3K27 demethylases in renal cell carcinoma

36 37 Background: Histone H3K27 demethylases UTX and JMJD3 are important regulatory factors 38 that modulate gene expression via altering the physical state of chromatin. Previous researches 39 have indicated abnormal status of H3K27 methylation caused in carcinogenesis, so we 40 investigated the expression pattern of UTX and JMJD3 in renal cell carcinoma (RCC) and their 41 role in cancer devel...

The end of a long search: at last thrombopoietin.